GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1061377 | 1 | rs12646251 | chr4:39134371 | KLHL5 | chr4:39046659-39123828:+ | -0.14 | -4.18 | 3.09E-5 | Uric acid levels |
| BRCA | cis | rs17030434 | 1 | rs12646758 | chr4:154731625 | RNF175 | chr4:154631313-154681387:- | -0.13 | -3.63 | 0.0003 | Electrocardiographic conduction measures |
| BRCA | cis | rs3796619 | 1 | rs12647929 | chr4:1092019 | CRIPAK | chr4:1385340-1389782:+ | 0.11 | 3.43 | 0.000618 | Recombination rate (males) |
| BRCA | cis | rs3796619 | 1 | rs12647929 | chr4:1092019 | KIAA1530 | chr4:1341104-1381836:+ | 0.11 | 3.58 | 0.00036 | Recombination rate (males) |
| BRCA | cis | rs1364989 | 1 | rs12648383 | chr4:55009315 | FIP1L1 | chr4:54243820-54326102:+ | 0.15 | 3.56 | 0.000392 | Lupus nephritis in systemic lupus erythematosus |
| BRCA | cis | rs7714584 | 1 | rs12652003 | chr5:150231945 | LOC134466 | chr5:150310000-150326146:- | 0.36 | 8.09 | 1.6E-15 | Crohn's disease |
| BRCA | cis | rs7714584 | 1 | rs12656600 | chr5:150311872 | LOC134466 | chr5:150310000-150326146:- | 0.37 | 8.47 | 8.36E-17 | Crohn's disease |
| BRCA | cis | rs6882076 | 1 | rs12657266 | chr5:156396003 | TIMD4 | chr5:156346293-156390266:- | -0.37 | -12.06 | 1.73E-31 | Triglycerides;Cholesterol, total;LDL cholesterol |
| BRCA | cis | rs2274459 | 1 | rs12660955 | chr6:33760320 | IP6K3 | chr6:33689443-33714762:- | 0.28 | 4.8 | 1.85E-6 | Obesity (extreme) |
| BRCA | cis | rs2274459 | 1 | rs12662447 | chr6:33714673 | IP6K3 | chr6:33689443-33714762:- | 0.24 | 4.17 | 3.29E-5 | Obesity (extreme) |
| BRCA | cis | rs1577917 | 1 | rs12663651 | chr6:86701655 | SNHG5 | chr6:86386726-86388451:- | -0.58 | -18.37 | 1.04E-65 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12663690 | chr6:86640162 | SNHG5 | chr6:86386726-86388451:- | 0.56 | 17.67 | 1.77E-61 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12664335 | chr6:86597774 | SNHG5 | chr6:86386726-86388451:- | 0.56 | 17.59 | 5.09E-61 | Response to antipsychotic treatment |
| BRCA | cis | rs14978 | 1 | rs12666249 | chr7:12260546 | VWDE | chr7:12370509-12443852:- | -0.13 | -3.44 | 0.000609 | Response to amphetamines |
| BRCA | cis | rs4731120 | 1 | rs12666309 | chr7:123412964 | HYAL4 | chr7:123485223-123517529:+ | 0.29 | 4.11 | 4.29E-5 | Platelet count |